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Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Deltasone is used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Since prednisone is used in much higher doses than the levels of corticosteroids produced naturally by the body. Prednisone to Prednisolone is impaired. Prednisolone is commonly used for several days before the needed effect is achieved. Prednisolone is a corticosteroid used to treat various inflammatory and allergy conditions as well as other diseases.